Frog medicine (called kambo), is a healing ritual from the Amazon involving poison from the giant Amazonian tree frog.

Venom is rubbed into small burn marks in the skin for the purpose of healing.

The venom of the Bufo alvarius toad contains one of the most psychoactive substances on Earth — 5-MeO-DMT.

Learn how toad venom works & how to use it safely.

Ayahuasca is a traditional entheogenic formula made from two Amazonia plant species — one containing DMT, the other an MAO inhibitor.

DMT is a powerful psychoactive compound found in ayahuasca, bufo toads, and a pure crystalline form called 5-MeO-DMT.