Category: Synthetic Psychedelics

Psychedelics can be either natural or synthetic.
Many (but not all) synthetic psychedelics were inspired or based on natural compounds.
For example, the largest class of synthetic psychedelics is the phenethylamine class, which is based on the structure of mescaline (the active ingredient in San Pedro or Peyote cactus).
Another famous synthetic psychedelic is LSD — which was a chemically-altered version of ergotamine from the ergot fungus.
Substances are tweaked and adapted in a lab to slightly alter its chemical structure — producing an entirely new compound.
There are thousands of synthetic psychedelics in the world today — largely created in response to the efforts of the drug war to ban psychoactive substances. Most of them are considered research chemicals because they lack sufficient scientific research to elucidate their mechanism of action or short/long-term safety profiles.
Naturally-occurring psychedelics can also be made synthetically, such as 5-MeO-DMT which is found naturally in the Colorado River Toad.

LSZ is an analog of LSD discovered by Dr. David Nichols. Preliminary research suggests this psychedelic compound is even stronger than LSD.

ETH-LAD is an analog of LSD. Its effects were first outlined by David Nichols, followed by the first rip report by Alexander Shulgin in his book TiHKAL.

AL-LAD is an analog of LSD that's said to have gentler effects. While it's undeniably milder, it's still a formidable psychedelic. Dosage, safety, & effects.

Ketamine powerful hallucinogenic compound similar to PCP. It's shown a lot of promise recently as a new treatment candidate for depression.

4-AcO-DMT — AKA synthetic shrooms — is a prodrug of a psychoactive ingredient in magic mushrooms (psilocin).

P-LSD (1-propionyl-lysergic acid diethylamide) is an analog of LSD-25 with nearly identical effects. 1P-LSD is legal in several countries.

MDMA is more than just a party drug. Evidence suggests MDMA is an effective treatment for PTSD, social anxiety disorder, & more.

2C-E (2,5-dimethoxy-4-ethylphenethylamine) is a synthetic psychedelic substance related to mescaline & 2C-B.

2C-E is considered one of the more challenging psychedelics.

2C-B is a synthetic psychedelic with effects similar to LSD, psilocybin, & MDMA.

Despite being illegal in most parts of the world, 2C-B is one of the most popular mind-altering substances on Earth.